This insulin injection is a non prescription item and can
be ordered without prescription
Lantus insulin injection) is an injectable non prescription
insulin from Aventis Pharmaceuticals. This insulin is the
first insulin to offer truly flat insulin levels through the
entire day for most users. Lantus insulin can be used by people
with Type 1 or Type 2 diabetes and who are six years old or
older. This injection is an alternative to an insulin pump,
it is the first long-term insulin that has a predictable and
consistent insulin activity.
The following are tips for using Lantus
It is recommended to take Lantus at bedtime. Lantus' actual
duration of action is 18 to 26 hours. Although the timing
varies from indiviual to individual, it appears to be consistent
in the same indiviual. The advantage to bedtime dosing is
that for most people any gap in Lantus' activity would happen
after dinner and this gap could be covered with a little extra
Humalog or Novolog in the dinner injection.
Whether you take it at bedtime or breakfast, it helps to be
consistent about timing, so pick a time when you will remember
to take the injection at the same time each day.
Lantus is a clear insulin which is unlike other long-acting
insulins (Lente, NPH, Ultralente) that are all cloudy. Although
the bottles have a different shape, some users have already
injected a bedtime dose of Humalog rather than Lantus! Be
very careful not to confuse Lantus with Humalog and other
clear insulins.
DO NOT MIX Lantus with any other insulin. Do not even reuse
a syringe in Lantus that has come in contact with another
insulin.
Lantus becomes inactivated if it comes in contact with even
small amounts of other insulins. This makes it appear hazy.
Never use any Lantus that is not crystal clear.
Lantus cannot replace the need for Humalog or another fast
insulin to cover carbs in meals. However, occasionally in
people with Type 2 diabetes, when the before breakfast blood
sugar is normalized with Lantus, a premeal medication like
Starlix, Prandin, or even Precose may be able to control the
post meal blood sugars.
Making LANTUS part of your regular daily insulin treatment
routine can be easier when you become more familiar with how
to inject insulin with your insulin vial and syringe setup.
Be sure to always follow your healthcare provider's recommendations.
How Lantus Works
This insulin analog was designed to have low solubility in
water at a neutral pH, such as that found in body fluids and
other insulins. Lantus becomes completely soluble only at
an acid pH of 4. Once this is injected under the skin, the
acidic solution is neutralized leading to the formation of
microprecipitates. The microprecipitates allow small amounts
of insulin to be released slowly, resulting in a relatively
constant concentration/time profile over 22 hours +/- 4 hours
with no pronounced peak in activity.
Lantus was modified to allow this precise action. Normal
insulin has two protein chains called A and B that have two
zinc crosslinks between them. Lantus differs from other insulins
in that one asparagine at position A21 of the A chain is replaced
by glycine, and two arginines have been added added to one
end of the B-chain.
DOSAGE AND ADMINISTRATION
LANTUS is a recombinant human insulin analog. Its potency
is approximately the same as human insulin. It exhibits a
relatively constant glucose-lowering profile over 24 hours
that permits once-daily dosing.
LANTUS may be administered at any time during the day. LANTUS
should be administered subcutaneously once a day at the same
time every day. For patients adjusting timing of dosing with
LANTUS, see WARNINGS and PRECAUTIONS, Hypoglycemia. LANTUS
is not intended for intravenous administration (see PRECAUTIONS).
Intravenous administration of the usual subcutaneous dose
could result in severe hypoglycemia. The desired blood glucose
levels as well as the doses and timing of antidiabetes medications
must be determined individually. Blood glucose monitoring
is recommended for all patients with diabetes. The prolonged
duration of activity of LANTUS is dependent on injection into
subcutaneous space.
How Often Does Lantus Fail To Work?
How many people fail to respond to Lantus is unknown. The
vast majority of users get a consistent action from this insulin
every day. However, Aventis' clinical studies did pick up
some individuals who had marked differences in the action
time for Lantus from one day to the next. In rare individuals,
it's action time was as short as 11 hours, but it is unknown
why this difference occurs.
Lantus (Insulin glargine) is a synthetic, recombinant DNA
human insulin which is created through genetic engineering.
Lantus (Insulin glargine) starts to work within one to two
hours and continues acting for about 24 hours. Lantus is different
from other forms of insulin in that is does not have a peak
effect. Instead, it lowers blood sugar a relatively constant
amount during the 24-hour period it is in the body.