| Anipryl is for the control of clinical signs associated with canine Cognitive Dysfunction Syndrome. Anipryl can be prescribed by your veterinarian after a diagnosis of CDS has been determined. Anipryl comes in a convenient tablet form for easy dosing. Most dogs are prescribed one tablet each day, preferably in the morning. (Anipryl can be given with food.) It's important to administer every tablet as directed since interruption of therapy could lead to the reappearance of signs.
Cognitive Dysfunction Syndrome
Researchers believe Cognitive Dysfunction Syndrome (CDS) is caused by physical and chemical changes that affect the brain function in older dogs. Dogs with CDS may show signs of confusion and/or various other behavioral changes that are not a normal part of aging. This confusion can lead to a life of lonely isolation, separated from family members who have come to cherish their older dog's companionship. This can be as hard on family members as it is on the dog. Pet owners often describe their dogs as less responsive, forgetful or confused.
In studies, pet owners reported that 69 to 75% of dogs improved in at least one clinical sign after one month of Anipryl therapy. Because CDS is a syndrome (a collection of signs), no two dogs will show exactly the same signs. Response to Anipryl may vary from dog to dog. The most common side effects are vomiting, diarrhea or changes in behavior such as hyperactivity and restlessness. Most side effects are mild to moderate. Consult your veterinarian before using Anipryl with other medications or with tick collars. As dogs grow older, they are likely to experience more health problems. Senior dogs should be observed more closely because changes in normal appearance, activity and behavior all can be signs that veterinary attention may be needed.
Anipryl Dosage and Administration: Cognitive Dysfunction Syndrome: Orally administer 0.5-1.0 mg/kg once daily, preferably in the morning.
Pituitary Dependent Hyperadrenocorticism: Orally administer 1 mg/kg once daily, preferably in the morning.
Anipryl Indications: Anipryl tablets are indicated for the control of clinical signs associated with canine cognitive dysfunction syndrome (CDS) and control of clinical signs associated with uncomplicated canine Pituitary Dependent Hyperadrenocorticism (PDH).
Anipryl Contraindications: Anipryl is contraindicated in patients with known hypersensitivity to this drug. In humans, selegiline is contraindicated for use with meperidine and this contraindication is often extended to other opioids.
Anipryl Warnings:
Keep out of reach of children. Not for human use.
Anipryl should not be administered at doses exceeding those recommended
Avoid the combination of Anipryl and selective serotonin reuptake inhibitors (e.g., fluoxetine) as well as Anipryl and tricyclic (e.g., clomipramine, amitriptyline, imipramine) or other antidepressants.
At least 14 days should elapse between discontinuation of Anipryl and initiation of treatment with a tricyclic antidepressant or selective serotonin reuptake inhibitor. Because of the long half-life of fluoxetine and its active metabolites, at least 5 weeks should elapse between discontinuation of fluoxetine and initiation of treatment with Anipryl.
General: Anipryl is not recommended for other behavior problems such as aggression. In the clinical trials, 3 dogs showed an increase in aggression while on this drug. The safety and efficacy of Anipryl has not been evaluated in dogs with debilitating systemic diseases other than PDH.
Anipryl Reproductive Safety: The safety of Anipryl in breeding, pregnant and lactating bitches, and breeding dogs has not been determined.
Anipryl Adverse Reactions: In clinical trials, 404 dogs treated with Anipryl for as long as 18 months were monitored for the occurrence of adverse events. Many of the observations seen may be associated with the underlying disease (PDH or CDS), the advanced age of the patients or the development of unrelated concurrent disease. One index of relative importance, however, is whether or not a reaction caused treatment discontinuation. Eighteen dogs (4%) experienced one or more of the following adverse events that led either to discontinuation of therapy with Anipryl, dismissal from the study, or a reduction in dose: restlessness/agitation, vomiting, disorientation, diarrhea, diminished hearing, possible drug interaction (weakness, confusion, incoordination and "seizure-like" activity while being treated concurrently with metronidazole, prednisone, and trimethoprim sulfa), increase in destructive behavior in a dog with separation anxiety, anorexia, anemia, stiffness and polydipsia.
How Anipryl Supplied: Five tablet strengths are available in blister-packs of 30 tablets each: 2 mg, 5 mg, 10 mg, 15 mg, and 30 mg. Each box contains 1 blister pack (30 tablets).
Anipryl Storage: Store at controlled room temperature 20°-25°C (68°-77°F).
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