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Reasons Adequan is used and important information about this medication
Adequan, a brand of Polysulfated glycosaminoglycan, is an intramuscular injection primarily used in horses, and cannot be used for human consumption. Glycosaminoglycan maintains the turgidity and moisture retention between cellular spaces in articular joints. Trauma and degenerative diseases diminish the matrix components of cartilage. Polysulfated Glycosaminoglycan (PSGAG) mimics the composition of glycosaminoglycan normally present in the articular cartilage matrix, acting as a proteolytic enzyme inhibitor in cases of cartilage wear-and-tear. The PSGAG in Adequan can limit and prevent the impact of different diseases that target the joint. Furthermore, equine carpal and hock joint functions are diminished when synovial fluid protein levels increase, and synovial fluid hyaluronic acid concentration decreases due to trauma. PSGAG can address this problem by countering such effects, keeping the joints in good condition.
Although PSGAG is recommended for the treatment of joint dysfunction due to trauma, degeneration, and lameness of equine joints, it cannot be given intraarticularly. Adequan is a multi-dose drug given intramuscularly, and the injection site must be cleansed with the use of proper aseptic technique prior to administration. This drug can only be obtained with a prescription from a licensed veterinarian. It is available in 100 mg/mL solutions, which can be given in 20 mL, 30 mL, and 50 mL glass vials. The recommended dose is 500 mg every 4 days, for 28 days, although toxicity remains unknown. Studies were conducted with horses getting as high as 2,500 mg doses twice a week for twelve weeks. The tests showed no evidence of soreness at the affected joint. To maintain efficacy, Adequan IM should be stored at temperatures between 20°-25°C (68°-77°F). It cannot be mixed with other drugs or solvents, as the potency may decrease and adverse effects may surface; however, there are no known side effects and contraindications to the use of Polysulfated Glycosaminoglycan.
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