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Reasons Crestor is used and important information about this medication
An HMG-CoA reductase inhibitor, Crestor is a medication that inhibits synthesis of low density lipoprotein (LDL), thus inhibiting the hepatic synthesis of very low density lipoprotein (VLDL). This would decrease the lipid (fat) level of the person. This is indicated to reduce the total mortality and risk in major cardiovascular events. It is primarily prescribed in adults with increased risk of atherosclerosis. It is used also in adults with primary hypercholesterolemia, mixed dyslipidemia, and isolated hypertriglyceridemia together with diet and exercise. It may be indicated to familial hypercholesterolemia and may be used to delay progression of atherosclerosis.
Crestor has an initial dose of ten milligrams with a maximum dose of forty milligrams which may be given with or without food. It is contraindicated to persons hypersensitive to the drug or its ingredients. It is also not given to persons with active liver disorders. It cannot be used for pregnant and lactating mothers. Adjustment of the dose is needed for persons with history of large amount of alcohol intake and liver disease. Alcohol intake may increase the risk for hepatotoxicity. An adjusted dose is also needed for persons who are already taking the same class of drug. Persons taking the drug should stop the drug intake when renal impairment develops secondary to sepsis, hypotension, major surgery, trauma, and electrolyte disorder. Special monitoring of dosing on Asians is advised because they have the higher risks for high level of drug in the system.
Drugs that may have an interaction include warfarin, cyclosporine, gemfribrozil, lopinavir, antacids, azole antifungal, and macrolides. It may also cause an increase in CK, transaminase, glucose and bilirubin levels. Concurrent use of the drugs also causes thyroid abnormalities, dipstick positive protienuria, and microscopic hematuria.
Side effects of Crestor are headache, myalgia, asthenia, constipation, dizziness, nausea, abdominal pain, itchiness, rash, and urticaria. Rare cases may include myopathy, hypersensitivity reaction including angioedema, rhabdomyolysis, and pancreatitis.
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