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Reasons Efudex is used and important information about this medication
Efudex is an antineoplastic drug used to treat colon, rectal, breast, stomach and pancreatic cancer as well as early breast cancer, multiple actinic (solar) keratoses and superficial basal cell carcinoma. It is also used as a palliative treatment for advanced colorectal cancer. It is distributed in a cream, topical solution and injection forms.
Cancer is a neoplasm characterized by the uncontrolled growth of anaplastic cells that tend to invade surrounding tissue and metastasize to distant body sites. Each cancer is distinguished by the nature, site or clinical course of the lesion. The basis of the cancer is believed to reside in alterations in DNA genes usually at several loci but many potential causes are recognized. More than 80% of cancer causes are attributed to cigarette smoking, exposure to carcinogenic chemicals, ionizing radiation and ultraviolet rays. Common site for growth of malignant cells are skin, lungs, prostate, breast and colon.
Efudex is contraindicated to those who are hypersensitive to the drug and its components, those with bone marrow suppression, or potentially serious infection. It is also not for used to those who have poor nutritional state and those who have major surgery in the previous month. It is used cautiously in those who have received high dose pelvic radiation or alkylating drug and in those with impaired hepatic and renal function or widespread neoplastic infiltration of the bone marrow.
Special caution is required in preparation and administration of medication especially in cream and topical solution. Efudex may be mutagenic, teratogenic or carcinogenic in those who prepare and administer it. An antiemetic drug is usually given before administration of drug. The drug is incompatible to drugs such as aldesluekin, ampothericin B cholesterol complex, carboplatin, cisplatin, cytarabine, diazepam, doxorubicin, droperidol, epirubicin, fentyl citrate, morphine sulfate, and ondanstertan. Mixing the drug with these incompatibilities may cause adverse effects.
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