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Reasons Zofran is used and important information about this medication
Zofran is not indicated for all individuals experiencing nausea and vomiting, some medical conditions may contraindicate the use of the drug. The attending physician is responsible for determining the safety of Zofran to patients since this drug can cause hypersensitivity reactions and it can cause various complications when administered to patients with existing medical conditions that contraindicates the use of Zofran.
Zofran can never be used with apomorphine. Apomorphine is a non-selective dopamine agonist that is used to treat patients suffering from Parkinson’s disease, erectile dysfunction and Alzheimer’s disease. When Zofran is used with apomorphine, marked hypotension can occur which is sometimes accompanied by loss of consciousness.
A hypersensitivity to any of the drug’s active and inactive ingredients is another contraindication for the use of Zofran. Hypersensitivity to Zofran can present as abnormalities in the ECG tracings. The drug can cause prolongation of the QT interval which can predispose the patient to experience another form of cardiac dysrhythmia called Torsades de Pointes. These cardiac dysrhythmias can cause sudden death if not corrected immediately. In order to avoid such complications, Zofran should never be prescribed to patients with congenital long QT syndrome. A patient who developed a hypersensitivity reaction to Zofran should be hooked to a cardiac monitor to examine the cardiac status of the patient.
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