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Drug Info, Side Effects and Efudex taking information for our customers
A DNA and RNA synthesis inhibitor, Efudex belongs to the pyrimidine analog class. It is used as a palliative treatment in advanced cases of colon cancer. It is also used as an early treatment for breast cancer. It can also be used to treat colon, rectal, breast, stomach and pancreatic cancer, multiple actinic kertoses and superficial basal cell carcinoma.
Efudex is contraindicated for those have hepatic or renal impairment, low immunity, neoplastic infiltration of the bone marrow and whose bone marrow suppression. A topical form of the drug is not recommended to use in pregnant woman. Sun exposure is also not allowed during therapy because it may cause photosensitivity reaction. Laboratory test such as liver function test may have an increased result while using the drug. It may also decrease granulocyte, platelet, red blood cell and white blood cell count.
Some of Efudex’s adverse effects that you may watch out are: acute cerebellar syndrome, confusion, euphoria, ataxia, weakness, malaise, chest pain, myocardial ischemia, thrombophlebitis, epistaxis, photophobia, nystagmus, visual changes, eye irritation, stomatitis, gastrointestinal ulcer, nausea, vomiting, leukopenia, anemia, dermatitis, pigmented palmar creases, and anaphylaxis.
When creams and topical solutions are used, be careful not to put some drug to the eyes, nose and mouth. Never put an occlusive dressing to the site when cream is used because it increases the risk for inflammatory reaction to adjacent normal skin. When applying the drug make sure that you are using a nonmetal component or wear gloves and wash your hand immediately after administration.
Watch out for signs of toxicity such as stomatitis and diarrhea. Hair loss may occur but is reversible. You may use sun block to help protect skin from skin irritation. Woman in child bearing age is advice to use an effective birth control method to prevent from getting pregnant during the course of the treatment. Breast feeding is also not allowed when using the drug.
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