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Clonidine information for people that are required to take this medicine
Clonidine, primarily used as an antihypertensive agent, is the generic name of Catapres. However it now sees widespread use in a number of other fields, for example, as an additive to anesthetics.
It has been found to reduce hyperactivity especially in children with ADHD. However, tolerance can develop for the drug and can lead to withdrawal symptoms when taken off the drug. It is usually necessary to continue taking the drug for some time after the condition for which it was prescribed has been cured.
Clonidine is delivered as Clonidine hydrochloride which is both an imidazoine derivative and a mesomeric compound. When administered, it is transported by lipids by bonding to albumin.
Catapres is administered orally, by transdermal patch, or by epidirial injection. The action of this drug starts by stimulating the alpha-adrenergic receptors in the brain stem. Sympathetic outflows from the central nervous system are lowered, leading to a decrease in peripheral resistance, renal vascular resistance and blood pressure (after 30 to 60mins).
Drug Interactions:
This medication can increase the effects of sedatives. Examples of these drugs include narcotic pain relievers, barbiturates, sedatives such as alprazolam (Xanax) and clonazepam (Klonopin) as well as ethanol. Tricyclic antidepressants, for example, amitriptyline (Elavil,Indep), imipramine (Tofranil), desipramine (Norpramin), and clomipramine (Anafranil) can block the blood pressure lowering effects of Catapres. This may cause blood pressure to rise.
It should be used cautiously in persons who are receiving other medications that lower heart rate such as beta-blockers: atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal), digoxin (Lanoxin), diltiazem (Cardizem or verapamil (Calan; Covera HS). This medication reduces heart rate. Abnormal heart rhythms can occur with the combination of clonidine and verapamil.
Cyclosporine (Sandimmune, Neoral) concentrations in the blood can increase when clonidine is begun. Kidney damage from the increased levels of cyclosporine may occur. Nonsteroidal antiinflammatory drugs (NSAIDs), for example, ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve), and nabumetone (Relafen) can reduce the antihypertensive effects of clonidine.
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