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Danazol information for people that are required to take this medicine
Danazol is used for the treatment of endometriosis which can be relieved by hormonal management. It can also be used in most cases of symptomatic fibrocystic breast disease, which are severe enough to need medications. Danazol can be used in decreasing symptoms associated with nodularity, pain, and tenderness in the breasts. It can also be used for the prevention of cutaneous, abdominal, and laryngeal angioedema in males and females.
Contraindications:
Danazol cannot be administered in people who have porphyria, impaired heart, liver, or kidney function, and those with undiagnosed abnormal genital bleeding. It cannot also be used by those who are pregnant or are breastfeeding. Since the use of the drug may cause fluid retention or edema in some people, those who have epilepsy, migraine, cardiac or kidney function requires careful observation.
Dosage and Administration:
For those who are experiencing infertility due to endometriosis, an initial dose of 800 mg given in two equally divided doses may be recommended. Desired effects such as the absence of menstruation and relief of pain is best achieved at 800 mg levels. For milder cases, an initial therapy of around 200 mg to 400 mg given in two equally divided doses may be prescribed. During the course of therapy, the dose may be adjusted depending on the patient’s response.
For the treatment of fibrocystic breast disease, the dosage ranges from around 100 mg to 400 mg given in two divided doses. Breast pain and tenderness are relieved in the first 3 months. Elimination of nodularity is witnessed within 4 to 6 months of uninterrupted therapy. For the treatment of hereditary angioedema in males and females, the dosage is usually individualized. A starting dose of around 200 mg two to three times a day may be recommended. This may be increased or decreased depending on the response to therapy.
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