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What is Generic Tazorac alternative and information for taking this drug
A new antipsoriatic drug, Tarazotene is a topical medication that is primarily used to treat the following conditions: psoriasis, acne, and photodamage.
Mechanism of Action:
The mechanism of action of Tarazotene is unknown but it is thought that the tazarotenic acid (the active form of this drug), binds to all the three members of the retinoic acid receptor. On the contrary, it shows a relative selectivity for retinoic acid receptor B (beta) and retinoic acid receptor G (gamma) and it may also modify its gene expression.
In psoriasis, it is believed that the use of topical this drug blocks the production of epidermal ornithine decarboxylase activity (ODC). This is associated with the cell proliferation and hyperplasia. It suppresses the expression of MRP 8 (an inflammatory marker present in psoriatic epidermis at high levels). In acne, this medication is believed to normalize the keratinization and reduces the coherence of follicular keratinocytes. This results to a comedolytic effect against the existing comedones and stops the development of new microcomedones.
Contraindications:
-pregnant women
-hypersensitivity to the drug or to other retinoic compounds
-children less than 12 years old
Side Effects:
-itching
-dry skin
-redness
-irritation
-burning or stinging sensation
-pain
Possible Serious Effects:
-rash
-swelling of the tongue
-swelling of the throat
-facial edema
-severe dizziness
-photosensitivity
-difficulty of breathing
Here are some important things that we have to consider in using Tarazotene:
-Apply this topical medication to the skin lesions using an aseptic technique.
-It is not used in eczematous skin.
-During application, keep this medication away from the eyes, nose, mouth and other mucous membranes. In case of contact, flush it using cold water.
-Be familiar with the side effects and adverse reactions of this topical medication. If you notice any adverse effects, notify the health care provider immediately.
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