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Imipramine and other antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal attempts and provide other important benefits. It also causes sedation. Therefore, it is useful in depressed patients with insomnia, restlessness, and nervousness.
Elderly persons and patients with advanced liver disease may need lower doses since they may eliminate the drug less from the body. Mood elevation occurs only in depressed individuals, and not in individuals without depression. It may take 2-3 weeks of therapy before effects are seen.
Initial dose for 65 years and older is 30 to 40 mg per day, it may gradually increased as required. However, it is generally not necessary to exceed 100 mg per day. But if the doctor prescribed a certain dose for you, follow the said prescription.
Most physicians prefer to give Imipramine once daily, in which case it is generally given at bedtime to take advantage of its sedating properties.
Drinking alcohol is strictly prohibited. It can cause dangerous side effects when taken together with the drug. Overdose with it can also cause life-threatening abnormal heart rhythms or seizures. After prolonged therapy of the drug in high doses, abrupt discontinuation of the medication could lead to certain cholinergic symptoms such as nausea, vomiting, or diarrhea. Therefore, many experts recommend gradually reducing the dose of drug if it has to be discontinued.
Although Imipramine is not addicting, withdrawal symptoms, including nervousness, anxiety, restlessness, akathisia, nausea, malaise, sweating and salivation have been reported after abrupt discontinuation
Before taking the drug, elders are required to check with their physician if the possess the following: alcohol intoxication; increased pressure in the eye; closed angle glaucoma; recent heart attack; abnormal heart rhythm; chronic heart failure; stroke; paralysis of the intestines; blocked bowels with no movement; liver problems; kidney disease; enlarged prostate; recent operation; feeling faint; seizures; cannot empty bladder; overactive thyroid gland; schizophrenia; manic-depression and having thoughts of suicide.
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