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Why is Isosorbide prescribed?
Isosorbide is prescribed to prevent angina pectoris (crushing chest pain that results when partially clogged arteries restrict the flow of needed oxygen-rich blood to the heart muscle). This medication does not relieve angina attacks already underway.
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Most important fact about Isosorbide
Isosorbide may cause severe low blood pressure (possibly marked by dizziness or fainting), especially when you are standing or if you sit up quickly. People taking blood pressure medication or those who have low blood pressure should use Isosorbide with caution.
How should you take Isosorbide?
To maintain this drug's protective effect, it is important that you take it exactly as prescribed. Take Isosorbide once a day, when you get up in the morning. It may be taken with or without food. Isosorbide tablets should not be crushed or chewed. Swallow them with half a glass of liquid. Do not switch to another brand of isosorbide mononitrate without consulting your doctor or pharmacist. --If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time. --Storage instructions...
Store at room temperature.
What side effects may occur with Isosorbide
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Isosorbide. Headache is the most common side effect; usually, aspirin or acetaminophen will relieve the pain. The headaches associated with Isosorbide usually subside within a short time after treatment with the drug begins. Check with your doctor if your headaches persist or become more intense. Another common side effect is dizziness.
Less common or rare side effects may include:
Abdominal pain, abnormal hair texture, abnormal heart sounds, abnormal or terrifying dreams, abnormal vision, acne, anemia, anxiety, back pain, bacterial infection, black stools, breast pain, bronchitis, chest pain, confusion, constipation, coughing, decreased sex drive, depression, diarrhea, difficult or labored breathing, difficulty concentrating, diminished sense of touch, drooping eyelid, dry mouth, earache, excessive amount of urine, fatigue, fever, fluid retention and swelling, flu-like symptoms, flushing, frozen shoulder, gas, general feeling of illness, heart attack, heart failure, heart murmur, hemorrhoids, high blood pressure, hot flashes, impotence, inability to sleep, increased mucus from the lungs, increased sweating, indigestion, inflamed eyes, inflammation of the stomach, inflammation of the tongue, inflammation of the vagina, intolerance of light, irregular heartbeat, itching, joint pain, kidney stones, leg ulcer, loose stools, low blood pressure, migraine, muscle and/or bone pain, muscle weakness, nasal or sinus inflammation, nausea, nervousness, palpitations (throbbing or fluttering heartbeat), paralysis, perforated eardrum, pneumonia, purple or red spots on the skin, rapid heartbeat, rash, ringing in the ears, severe pain in calf muscles during walking, sleepiness, slow heartbeat, sore throat, stomach ulcer with or without bleeding, stuffy nose, tingling or pins and needles, tremor, twisted neck, urinary tract infection, varicose veins, vertigo, viral infection, vomiting, weakness, wheezing, worsening of angina pectoris, yeast infection
Possible food and drug interactions when taking Isosorbide
If Isosorbide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Extreme low blood pressure with dizziness and fainting upon standing up may occur if Isosorbide is taken with the impotence drug Viagra or calcium-blocking blood pressure medications such as Calan, Cardizem, and Procardia.
Alcohol may interact with Isosorbide and cause a swift decrease in blood pressure, possibly resulting in light-headedness.
Special information if you are pregnant or breastfeeding when taking Isosorbide
The effects of Isosorbide during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, tell your doctor immediately. Isosorbide should be used during pregnancy only if it is clearly needed.
It is not known whether Isosorbide appears in breast milk. If the drug is essential to your health, your doctor may advise you to stop nursing until your treatment is finished.
Recommended Isosorbide dosage
ADULTS The usual starting dose is 30 milligrams (taken as a single 30-milligram tablet or as one-half of a 60-milligram tablet) or 60 milligrams once a day.
After several days, your doctor may increase the dose to 120 milligrams (a single 120-milligram tablet or two 60-milligram tablets) once daily. Your doctor may further adjust the dosage according to your response to the medication.
CHILDREN Safety and effectiveness of Isosorbide in children have not been established.
Isosorbide Overdosage
Any medication taken in excess can have serious consequences. Severe overdosage of Isosorbide can be fatal. If you suspect an overdose, seek medical help immediately.
Symptoms of Isosorbide overdose may include:
Air hunger, bloody diarrhea, coma, confusion, difficulty breathing, fainting, fever, nausea, palpitations, paralysis, pressure in the head, profuse sweating, seizures, skin either cold and clammy or flushed, slow heartbeat, throbbing headache, vertigo, visual disturbances, vomiting
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