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Januvia drug description and what Januvia is used to treat
Januvia is an oral hypoglycaemic that helps diabetics control their blood glucose levels. It is classified under the generic name Sitagliptin Phosphate. When a meal is consumed, the intestines release hormones called incretins, which reduce glucose concentrations. After a while, dipeptidyl peptidase, an enzyme which inactivates incretins is released.
Incretins then have very short life spans, because they are immediately broken down by the said enzyme. Sitagliptin is a dipeptidyl peptidase-4 inhibitor that counters the inactivation of incretin hormones. It increases concentrations of active hormones as well. This prolongs the effect of incretins, and ultimately lowers blood glucose levels. Because of this mechanism, Januvia is also known as an incretin enhancer.
Indications and Contraindications:
Januvia is primarily indicated for those with type 2 Diabetes mellitus. It is an adjunct medication therapy to diet and exercise for better blood sugar control. It can also be used as a monotherapy (by itself), or with metformin along with diet and exercise if monotherapy does not provide enough glycemic control. This isn’t for those afflicted with type 1 Diabetes mellitus. Caution is given to those with a history of kidney or pancreatic disease.
Other drugs such as probenecid, NSAIDs, salicylates, sulfa drugs, monoamine oxidase inhibitors, and beta-blockers when taken together with Sitagliptin may further lower blood glucose levels and lead to hypoglycemia. There are more food, drugs, and herbs that can have an interaction, therefore it is important to give a complete list to your doctor. For pregnant women may purchase this drug as no known effect have been documented to harm an unborn baby. If you experience hives, difficulty of breathing, swelling, fever, sore throat, and pancreatitis, stop taking the medicine and immediately contact your physician. Less serious expected side effects may include colds, sore throat, headache, nausea, stomach pain or diarrhea.
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