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Methotrexate information for people that are required to take this medicine
Methotrexate is a folic acid antagonist from the class of antimetabolites drug. It is also known as MTX. This was discovered in 1948, and was used for treating both cancerous and noncancerous conditions.
Drug Action:
The inhibition of folic acid reductase is the result of the anti-tumor activity of this drug. This leads to the inhibition of DNA synthesis and inhibition of cellular replication.
This medication can be given orally, intravenously, or intramuscularly. It is absorbed in from the gastrointestinal tract and peaks 1 hour, with peak concentration in 3 to 12 hours.
This medication may be given in cancerous conditions such as trophoblastic tumors, acute lymphocytic leukemia, meningeal leukemia, Burkitt’s lymphoma, lymphosarcoma, osteosarcoma, breast cancer, and mycosis fungoides. This medication may be given in noncancerous conditions such as psoriasis and rheumatoid arthritis.
This medication is not given in patients who have hypersensitivity to the drug. It is not given to patients who have psoriasis or rheumatoid arthritis who also have alcoholism, alcoholic liver, chronic liver disease, immunodeficiency syndromes, or blood dyscrasias. Pregnant or breastfeeding women are also not allowed to take this drug.
This medication should be used cautiously in very young, elderly, or debilitated patients and in those with infection, peptic ulceration, or ulcerative colitis. This should also be used cautiously and at modified dosage in patients with impaired hepatic or renal functions, bone marrow suppression, aplasia, leucopenia, thrombocytopenia, or anemia.
In using this drug, there are important things that you have to remember. Encourage patient to increase fluid intake of 2 to 3 L daily. You need to monitor fluid intake and output daily. You also need to monitor pulmonary function tests and uric acid periodically. You also have to observe for signs and symptoms of bleeding and infection, and to tell their health care provider if any of these occur.
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