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Mirtazapine information for people that are required to take this medicine
Tricyclic antidepressants like Mirtazapine are used to treat major depressive disorders. It is available in 15 mg, 30mg and 45 mg tablet. This drug is absorbed rapidly (bioavailability 50%) and able to reach plasma levels in just about 2 hours. The intake of food with the drug shows no influence on its pharmacokinetics. Therefore, this tablet can be taken with or without food.
Mirtazapine is administered orally and once a day. Intake of more than 45 mg in a day will cause an overdose and may lead to some complications. It is necessary to adhere on the dosage regimen prescribed by the doctor. This drug is distributed throughout the body by binding almost 85% of its active ingredient to plasma protein. Approximately, the mean half- life elimination of the medication is between 20-40 hrs. That is the reason why it is suggested as once a day dosing.
Oral intake of this antidepressant drug should be under medical supervision. Possible serious side effects may occur if taken concomitantly with other drugs. Alcohol intake is not permitted, since this can alter the efficacy of the drug. Inform your doctor for any existing diseases or if you are taking other medications, including herbal medicines, food supplements and other OTC (over the counter) drugs.
Mirtazapine antidepressant drug is metabolized in the liver. As the mode of elimination, it is excreted via urine and feces, few days upon administration. However, studies have not yet proved if the active ingredient Mirtazapine can be excreted in the breast milk. Therefore, it should not be used for breastfeeding moms. This has been categorized in Category C under US FDA pregnancy. No animal studies have been conducted about the safety of the medication on pregnant women. Advise your doctor if you are having a baby prior to the drug intake.
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