Premplus is manufactured by Wyeth-Ayerst. Premplus is taken as two pills everyday. In the US, both ingredients are combined into one pill so that you would only take one pill daily. However, in Canada, the two ingredients are made into separate pills. This medicine is an estrogen and progesterone combination used to treat the symptoms of menopause. It may also be used to treat certain menstrual disorders, osteoporosis, or other conditions as determined by your doctor. Alternative medicines to prevent bone loss (osteoporosis) include raloxifene and bisphosphonate drugs such as alendronate.

 

Where can I order Premplus from? Can I buy Premplus at Canadian Prices?

Yes, if you are from the U.S. then you can buy Premplus at Canadian prices. Currently we will only accept an order for Premplus from U.S. and Canadian residents. Both U.S. and Canadian residents require a prescription to purchase Premplus and when you order Premplus it will be delivered with express shipping.

Why is Premplus prescribed?

Premplus is an estrogen replacement drug. The tablets are used to reduce moderate to severe symptoms of menopause, including feelings of warmth in the face, neck, and chest, and the sudden intense episodes of heat and sweating known as "hot flashes." Cenestin tablets, containing a synthetic form of conjugated estrogens, may also be prescribed for these symptoms. In addition to the symptoms of menopause, Premplus tablets are prescribed for teenagers who fail to mature at the usual rate, and to relieve the symptoms of certain types of cancer, including some forms of breast and prostate cancer. In addition, either the tablets or Premplus vaginal cream can be used for other conditions caused by lack of estrogen, such as dry, itchy external genitals and vaginal irritation. Along with diet, calcium supplements, and exercise, Premplus tablets are also prescribed to prevent postmenopausal osteoporosis, a condition in which the bones become brittle and easily broken. Before taking Premplus solely for this purpose, you should carefully consider using alternative, nonestrogen therapies.

The addition of progesterone to estrogen-replacement therapy has been shown to reduce the risk of uterine cancer. Prempro combines estrogen and progesterone in a single tablet taken once daily. Premphase is a 28-day supply of tablets. The first 14 contain only estrogen. The second 14 supply both estrogen and progesterone. Both Prempro and Premphase are prescribed to reduce the symptoms of menopause, including vaginal problems, and to prevent osteoporosis.

Most important fact about Premplus

Because estrogens have been linked with an increased risk of uterine and endometrial cancer (cancer in the lining of the uterus), it is essential to have regular checkups and to report any unusual vaginal bleeding to your doctor immediately.

Premplus and other estrogen drugs, with or without progesterone, should not be used to prevent heart disease. Recent studies have confirmed an increased rate of heart attack, stroke, and dangerous blood clots among women taking estrogen or estrogen combinations for 5 years. Blood clots can lead to phlebitis, stroke, heart attack, a loss of blood supply to the lungs, a blockage in the blood vessels serving the eye, and other serious disorders.

How should you take Premplus?

Take Premplus exactly as prescribed. Do not share it with anyone else. If you are taking calcium supplements as a part of the treatment to help prevent brittle bones, check with your doctor about how much to take. You should take a few moments to read the patient package insert provided with your prescription. If you are using Premplus vaginal cream, apply it as follows:
1. Remove cap from tube.
2. Screw nozzle end of applicator onto tube.
3. Gently squeeze tube from the bottom to force sufficient cream into the barrel to provide the prescribed dose. Use the marked stopping points on the applicator as a guide.
4. Unscrew applicator from tube.
5. Lie on back with knees drawn up. Gently insert applicator deeply into the vagina and press plunger downward to its original position. To cleanse the applicator, pull the plunger to remove it from the barrel, then wash with mild soap and warm water. Do not boil or use hot water. --If you miss a dose...Take the forgotten dose as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Never try to "catch up" by doubling the dose. --Storage instructions...

Store Premplus at room temperature.

What side effects may occur with Premplus?

Premplus Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor immediately. Only your doctor can determine whether it is safe to continue taking Premplus.

Premplus Side effects of conjugated estrogens may include:
Abdominal cramps, abnormal vaginal bleeding, allergic reactions, bloating, blood clots, blood pressure increase, breast cancer or cysts, breast pain or discharge, breast swelling and tenderness, decreased calcium in the blood, depression, dizziness, endometrial cancer, endometrial cell changes, enlargement of benign tumors in the liver or uterus, fluid retention, gallbladder disease, hair loss from the scalp, hives, increased body hair, increased triglycerides, inflammation of the pancreas, intolerance to contact lenses, irritability, itchy spots, joint pain, leg cramps, migraine headache, nausea, mood disturbances, nervousness, ovarian cancer, painful menstruation, sex-drive changes, skin darkening (especially on the face), skin rash or redness, swelling of wrists and ankles, vaginal yeast infection, vomiting, weight gain or loss, worsening of asthma or epilepsy, yellow eyes and skin

Other possible Premplus side effects of Premphase and Prempro may include:
Appetite changes, backache, changes in blood pressure, excessive flow of breast milk, eye disorders, fatigue, fever, headache, nervousness, sleep disturbances, twitching

Other possible Premplus side effects of Cenestin may include:
Constipation, cough, diarrhea, gas, heavy bleeding during menstruation, increased heartbeat, increased muscle tone, indigestion, infection, joint pain, leg cramps, muscle pain, pain, painful menstruation, runny nose, skin tingling, sore throat, weakness

Why should Premplus not be prescribed?

Do not take Premplus if you have ever had a bad reaction to it, or have undiagnosed abnormal vaginal bleeding. Except in certain special circumstances, you should not be given Premplus if you have ever had breast cancer, uterine cancer, or any other "estrogen-dependent" cancer. Do not take Premplus if you have had any circulation problem involving blood clots, or have had a stroke or heart attack in the past year. Do not take Premplus if you have liver disease or your liver is not working properly.

Do not use Premplus if you are pregnant or trying to become pregnant.

 

Special information if you are pregnant or breastfeeding when taking Premplus

If you are pregnant or plan to become pregnant, notify your doctor immediately. Premplus and conjugated estrogens should not be taken during pregnancy because of the possibility of harm to the unborn child. Premplus cannot prevent a miscarriage. Estrogens can decrease the quantity and quality of breast milk, and progestins appear in breast milk. Your doctor may advise you not to breastfeed while you are taking this drug.

 

Premplus Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose of Premplus, seek medical attention immediately.

Symptoms of conjugated estrogen overdose may include:
Nausea, vomiting, withdrawal bleeding

 

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