Sabril
Brand Name
Sabril
Common Name
vigabatrin
Where can I order Sabril from? Can I buy Sabril
at Canadian Prices?
Yes, if you are from the U.S. then you can
buy Sabril at Canadian prices. Currently we will only accept
an order for Sabril from U.S. and Canadian residents. Both
U.S. and Canadian residents require a prescription to purchase
Sabril and when you order Sabril it will be delivered with
express shipping.
How does Sabril work? What will it do for me?
Vigabatrin belongs to the class of medications called anticonvulsants. It is used for the management and treatment of seizures, often in combination with other anti-seizure medications when other medications have not been beneficial. It is thought that Sabril works by increasing the levels of certain chemicals in the brain, making seizures less likely to occur. Vigabatrin is also used for the treatment of infantile spasms (West syndrome).
Your doctor may have suggested Sabril for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Sabril, speak to your doctor. Do not stop taking Sabril without consulting your doctor.
How should I use Sabril?
The recommended adult starting dose of vigabatrin is 1 gram (1,000 mg) daily. The recommended children's dose is based on body weight. Vigabatrin may be taken with or without food. The medication may be taken in tablet form or by using the powder (sachets) dissolved in 10 mL of either water, fruit juice, milk, or infant formula. Mix the powder just before you use it. The exact dosage should be measured and taken by use of an oral syringe.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is very important that you take Sabril exactly as prescribed by your
doctor. Do not stop taking your medication abruptly. Discontinuation
of your medication should take place gradually over a few
weeks and only in consultation with your doctor. Always check
that you have enough vigabatrin and that you do not run out
of medication. If you forget to take a dose, take it as soon
as you remember, and then continue as usual. However, if it
is almost time for your next dose, skip the dose you forgot,
and continue as usual.
Who should NOT take Sabril?
Vigabatrin should not be used by:
women who are or may be pregnant or who are breast-feeding
anyone allergic to vigabatrin or any of the ingredients of the medication
anyone who is currently taking medications which could be toxic to the retina of the eye
What side effects are possible with Sabril?
The side effects listed below are not experienced by everyone who takes Sabril. If you are concerned about side effects, discuss the risk and benefits of Sabril with your doctor. Your health professional may be able to help you to deal with some of the effects.
The following side effects may go away as your body becomes used to the medicine; check with your doctor if they continue or become bothersome:
More common:
abdominal pain
abnormal coordination
agitation
anxiety
clumsiness
confusion
constipation
depression
diarrhea
dizziness
drowsiness
double vision or "seeing double"
fatigue
hyperactivity
increased movement
joint pain
shakiness
sleepiness or unusual drowsiness
trembling
tremor
unsteadiness
Less common:
headache
impaired concentration
increased saliva
insomnia
muscle weakness
nausea
speech disorder
thinking abnormally
vomiting
weight gain
Contact your doctor immediately if any of the following side effects occur:
More common:
amnesia
blurred vision
blue-yellow colour blindness
decreased vision or other vision changes
eye pain
increase in seizures
Less common:
uncontrolled rolling eye movements
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Sabril.
Are there any other precautions or warnings for Sabril?
Eye problems: A number of different types of eye problems have been reported for people taking vigabatrin often in combination with other anti-epileptic medications. The onset of problems has occurred from less than one month to over six years after start of treatment. The onset of symptoms tends to be reported most frequently within the first year of treatment.
Eye examinations are recommended at the start of treatment with vigabatrin and should continue to take place every three months.
Anyone taking Sabril should report narrowing of the field of vision or loss of visual sharpness to their doctors and should be advised to promptly report any emerging visual problems.
The use of vigabatrin should be stopped if eye problems occur unless the benefit of controlling seizures through continued treatment outweighs the risk of visual impairment.
Kidney function: Vigabatrin passes from the body via the kidney. People with reduced kidney function should use Sabril with caution.
Medical conditions: People who have had psychiatric disorders or behavioural problems should use Sabril with caution.
Occupational hazards: People with uncontrolled epilepsy should not drive or operate potentially dangerous machinery. The most common side effects with vigabatrin are drowsiness and fatigue. People taking the medication are advised to avoid activities requiring mental alertness or physical coordination until they determine that vigabatrin does not affect them adversely.
Sudden discontinuation of medication: As with other anti-epileptic medications, stopping vigabatrin suddenly may lead an increased number of seizures. If possible, it is recommended that the dose be reduced gradually over a period of two to four weeks.
Pregnancy: Vigabatrin should not be used if you are pregnant. Before you take Sabril, tell your doctor if you are pregnant, likely to become pregnant, or planning to become pregnant. Tell your doctor immediately if you become pregnant or suspect that you may be pregnant during your treatment.
Breast-feeding: Vigabatrin passes into breast milk in low concentrations. Women should not nurse while taking Sabril.
What other drugs could interact with Sabril?
Other medications that have toxic effects on the eye may affect how vigabatrin works or increase the risk of side effects.
Vigabatrin may affect how the following medications work or increase side effects:
phenobarbital
phenytoin
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Sabril. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription) and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or illegal drugs can affect the action of many medications, you should let your prescriber know if you use them.
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