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Sulfasalazine information for people that are required to take this medicine
Sulfasalazine is a salicylate anti-inflammatory drug used to treat certain types of bowel diseases such as ulcerative colitis and Crohn’s Disease. Nevertheless, it does not cure the disease. It can only decrease the symptoms brought about by the disease such as stomach pain, diarrhea and rectal bleeding caused by irritation or swelling of the colon or rectum.
Sulfasalazine may cause reduced absorption of folic acid and digoxin (Lanoxin). Reduced folic acid absorption may cause folic acid deficiency and result in anemia. Hence, pregnant women and lactating mothers who are using this medicine must consult their physician.
Sulfapyridine is a sulfonamide, and sulfonamides increase blood levels of methotrexate (Rheumatrex, Trexall), resulting in increased methotrexate toxicity. The methotrexate can increase the occurrence of the anemia caused by sulfonamides because methotrexate also causes folic acid deficiency.
Sulfonamides can increase the risk of kidney damage from cyclosporine by an unknown mechanism. Thereby, it is necessary to consult your doctor if you have kidney or liver disease prior to medication.
They also may increase the blood glucose lowering effect of oral anti-diabetic drugs and potentially cause excessive reductions in blood sugar (hypoglycemia) by decreasing elimination of anti-diabetic drugs by the liver and elevating the levels of the anti-diabetic drugs in the blood.
During Sulfasalazine theraphy, headache, allergic reactions, and photosensitivity (development of a rash when exposed to sunlight) may develop thus requiring medical attention. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.
Some of the allergic reactions may progress from a rash to difficulty in swallowing, blistering, peeling, or loosening of the skin, aching joints and muscles, and unusual tiredness or weakness.
Sulfasalazine medication may rarely cause very serious allergic reactions (i.e. Stevens-Johnson syndrome), blood disorders (i.e. agranulocytosis, aplastic anemia), liver damage, and nerve/muscle problems.
Before using this medicine, consult your doctor or pharmacist if you have: intestinal blockage, urinary blockage, a certain blood disorder (porphyria).
While taking this medication, it is advised not to drive, use machinery or does any activity that requires mental and physical alertness, as the drug can make you dizzy. Wait until you can already know the effect of the drug on you and secure clearance from your doctor.
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