Tacrolimus is an immunosuppressant used to prevent rejection after a liver or kidney transplant. It may also be used to treat other conditions as determined by your doctor.
Brand Name
Prograf
Common Name
tacrolimus capsules
Where can I order Tacrolimus from? Can I buy Tacrolimus
at Canadian Prices?
Yes, if you are from the U.S. then you can
buy Tacrolimus at Canadian prices. Currently we will only accept
an order for Tacrolimus from U.S. and Canadian residents. Both
U.S. and Canadian residents require a prescription to purchase
Tacrolimus and when you order Tacrolimus it will be delivered
with express shipping.
How does Tacrolimus work? What will it do for me?
Tacrolimus belongs to the class of medications called immunosuppressants. It is used to prevent the body's rejection of a transplanted kidney or liver. Tacrolimus works by lowering the activity of white blood cells in the body (the cells that attack substances foreign to the body).
Your doctor may have suggested Tacrolimus for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Tacrolimus, speak to your doctor. Do not stop taking Tacrolimus without consulting your doctor.
How should I use Tacrolimus?
The dose of Tacrolimus varies according to circumstances and will be determined by your doctor. If you are unable to take capsules, the medication may be delivered by slow injection into a vein in the hospital.
You should try to take your doses of Tacrolimus at the same time every day. The doses should be spaced as evenly throughout the day as possible. Ask your transplant nurse or pharmacist about a dosing schedule that best fits your lifestyle. Tacrolimus may be taken with or without food, but it is best to be consistent. Tacrolimus should not be taken with grapefruit or grapefruit juice. The capsules should be swallowed whole and not cut, crushed, or chewed.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is very important that Tacrolimus be used exactly as prescribed by the doctor. If even a few doses of Tacrolimus are missed, your body may reject your transplanted organ. If you miss a dose of Tacrolimus, do not try to catch up on your own, but call your doctor or pharmacist right away for advice. It is also a good idea to ask your doctor ahead of time what you should do about missed doses. Be sure to order your medication refills well ahead of time.
Tacrolimus is often given with other medications. Make sure you know if
you are to stop or continue other immunosuppressive medications
you have been taking.
Who should NOT take Tacrolimus?
Tacrolimus should not be used by anyone allergic to Tacrolimus or to any of the ingredients of the medication.
What side effects are possible with Tacrolimus?
The side effects listed below are not experienced by everyone who takes Tacrolimus. If you are concerned about side effects, discuss the risks and benefits of Tacrolimus with your doctor. Your health professional may be able to help you deal with some of the effects.
Check with your doctor immediately if any of the following side effects occur:
More common:
abdominal pain
abnormal dreams
agitation
anxiety
chills
confusion
convulsions (seizures)
diarrhea
dizziness
fever and sore throat
flu-like symptoms
frequent urination
hallucinations
headache
infection
itching
loss of appetite
loss of energy or weakness
mental depression
muscle trembling or twitching
nausea
nervousness
pale skin
shortness of breath
skin rash
swelling of feet or lower legs
tingling
trembling and shaking of hands
trouble sleeping
unusual bleeding or bruising
unusual tiredness or weakness
vomiting
Less common:
blurred vision
chest pain
increased sensitivity to pain
muscle cramps
numbness or pain in legs
ringing in ears
sweating
Rare:
flushing of face or neck
general feeling of discomfort or illness
weight loss
wheezing
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Tacrolimus.
Are there any other precautions or warnings for Tacrolimus?
Blood pressure: Tacrolimus treatment commonly causes mild to moderate increases in blood pressure. Monitor your blood pressure, and inform your doctor if there is an indication that your blood pressure is rising.
Blood sugar: High blood sugar has been associated with the use of Tacrolimus. Your doctor will help to monitor this, but be sure to report any signs of high blood sugar (e.g., increased thirst, urination, unusual tiredness) to your doctor.
High potassium levels in the blood: Tacrolimus may cause an increase in potassium levels in the blood. Some foods (e.g., bananas or orange juice) and medications may increase the risk of this problem. Be sure to tell your doctor and pharmacist about all the medications you are taking (including non-prescription medications) and to talk to them about potassium-rich foods.
Infections: Tacrolimus reduces resistance to infections and may delay healing. Precautions should be taken to prevent exposure to circumstances that increase risk of infection (e.g., dental work).
Kidneys: Tacrolimus may affect kidney function. Your doctor will follow your kidney function through laboratory tests while you are taking Tacrolimus. Be sure to report to your doctor immediately any changes in kidney function such as appearance of urine, frequency of urination, and amount of urine produced.
Nerves: Tacrolimus may affect nerve function and cause symptoms such as tremor and headache. Be sure to report any changes to your doctor at once.
Pregnancy: Adequate studies have not been conducted on the use of Tacrolimus by pregnant women. However, the use of Tacrolimus during pregnancy has been associated with high blood potassium levels and kidney problems in the newborn. Tacrolimus should be used during pregnancy only if the potential benefits outweigh the potential risks.
Breast-feeding: Tacrolimus may pass from the blood into breast milk. A decision should be made to stop nursing or stop taking the medication, taking into account the importance of the medication to the mother.
What other drugs could interact with Tacrolimus?
The following foods or medications may affect how Tacrolimus works or increase the risk of side effects:
amphotericin B
aminoglycosides
epilepsy medications
bromocriptine
calcium channel blockers
cimetidine
cisapride
cisplatin
cyclosporine
danazol
ethinyl estradiol
grapefruit juice
ketoconazole
macrolide antibiotics
medications that increase potassium levels (e.g., ACE inhibitors, spironolactone)
methylprednisolone
metoclopramide
nefazodone
omeprazole
protease inhibitors
rifampin
St. John's Wort
vaccinations (live)
Tacrolimus may affect how the following medications work or increase the risk of side effects:
phenytoin
vaccinations
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Tacrolimus. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
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