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Trazodone information for people that are required to take this medicine
Trazodone is a triazolopyridine derivative antidepressant drug. Its mechanism of action is unknown but it inhibits the central nervous system neuronal uptake of serotonin. It is commonly mistaken as a tricyclic derivative. Their dispensing doses are in 50 mg, 100 mg, 150 mg, and 300 mg tablets.
The anti-depression drug’s initial dose is 150 mg by mouth daily in divided doses. Its maximum dose is 600 mg for those confined to the hospital and 400 mg for those staying at home.
Trazodone is contraindicated to those who are allergic to the drug and its components. Use cautiously in those who are in recovery stage from myocardial infarction or heart attack and those who have cardiac disease. It is also used in caution to those who are at risk for suicide.
Interactions:
• Amphetamines, buspirone, dextomethorphan, dihydroergotamine, lithium salt, meperidine, SSRIs, tricyclic antidepressant and tryptophan: It is known to increase the risk for a condition calledserotonin syndrome. Avoid combining drugs that increase the availability of serotonin in the central nervous system.
• Antihypertensive: It increases the hypotensive effect of the drug. The antihypertensive effect may be decreased while using with the drug.
• Clonidine, Central Nervous System depressants: It may enhance the central nervous system depression; avoid using together.
• Carbamazepine: May reduce the drug levels and effectiveness. Consider increase in dose when used with carbamazepine.
• Ketoconazole: May slow down the clearance of the drug to the body making it prone to toxicity. Consider decrease dose when used with ketoconazole.
• Digoxin, phenytoin: May increase levels of these drugs.
• MAO inhibitor
Trazodone has the following adverse effects that you should consider while taking the drug: drowsiness, dizziness, nervousness, fatigue, confusion, tremor, weakness, hostility, anger, nightmares, vivid dreams, headache, insomnia, syncope, orthostatic, hypotension, tachycardia, hypertension, shortness of breath, ECG and syncope.
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